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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFS
All Species:
22.73
Human Site:
S53
Identified Species:
41.67
UniProt:
P49914
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49914
NP_006432.1
203
23256
S53
Y
Q
K
S
K
R
I
S
I
F
L
S
M
Q
D
Chimpanzee
Pan troglodytes
XP_001154891
203
23207
S53
Y
Q
K
S
K
R
I
S
I
F
L
S
M
Q
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852666
203
23320
S54
Y
Q
K
S
K
R
I
S
I
F
L
S
M
H
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9D110
203
23183
S53
Y
Q
N
S
K
R
I
S
I
F
L
S
M
Q
D
Rat
Rattus norvegicus
NP_001009349
203
23222
S53
Y
Q
N
S
K
R
I
S
I
F
L
S
M
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516124
97
11478
Chicken
Gallus gallus
XP_413857
210
23450
A62
Y
Q
E
S
K
R
I
A
I
F
L
S
M
P
D
Frog
Xenopus laevis
NP_001089249
205
23364
N56
Q
R
V
A
V
F
L
N
M
S
D
E
I
Q
T
Zebra Danio
Brachydanio rerio
XP_002662791
199
22883
N55
Q
R
V
A
V
F
L
N
M
H
D
E
V
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097432
201
22863
S53
F
R
Q
A
Q
R
V
S
I
Y
L
S
T
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XWE6
206
23542
S55
K
R
L
S
V
Y
V
S
T
S
G
E
I
Q
T
Sea Urchin
Strong. purpuratus
XP_001183516
161
18411
V41
S
Q
N
K
L
C
Y
V
P
Q
Y
I
G
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40099
211
24040
G70
I
K
N
L
F
Q
D
G
Q
E
V
F
L
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
N.A.
86.2
N.A.
83.2
83.2
N.A.
35.4
66.6
55.6
60
N.A.
35.9
N.A.
37.8
42.3
Protein Similarity:
100
100
N.A.
94.5
N.A.
92.6
93
N.A.
43.3
80.9
80.4
80.3
N.A.
59.1
N.A.
55.8
59.1
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
93.3
N.A.
0
80
6.6
0
N.A.
33.3
N.A.
20
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
93.3
N.A.
0
93.3
46.6
40
N.A.
80
N.A.
40
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
24
0
0
0
8
0
0
0
0
0
16
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
0
16
0
0
0
47
% D
% Glu:
0
0
8
0
0
0
0
0
0
8
0
24
0
0
0
% E
% Phe:
8
0
0
0
8
16
0
0
0
47
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% H
% Ile:
8
0
0
0
0
0
47
0
54
0
0
8
16
0
0
% I
% Lys:
8
8
24
8
47
0
0
0
0
0
0
0
0
0
8
% K
% Leu:
0
0
8
8
8
0
16
0
0
0
54
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
16
0
0
0
47
0
0
% M
% Asn:
0
0
31
0
0
0
0
16
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
0
24
0
% P
% Gln:
16
54
8
0
8
8
0
0
8
8
0
0
0
47
0
% Q
% Arg:
0
31
0
0
0
54
0
0
0
0
0
0
0
0
8
% R
% Ser:
8
0
0
54
0
0
0
54
0
16
0
54
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
24
% T
% Val:
0
0
16
0
24
0
16
8
0
0
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
47
0
0
0
0
8
8
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _